Abstract

Hanan A. Mohalhal*, Khaled G. Abdel-Wahhab, Abdel-Rahman B. Abdel-Ghaffar and Magdy M. Mohammad

ABSTRACT

Hepatotoxicty, the most important problem worldwide gets the most attention from scientists as it considered a lethal disease. It arises as a side effect of many drugs, Alcohol abuse, liver malfunction and others. RimactazidR (RimR) is the first line drug for tuberculosis causes hepatotoxicity. Our study asses the hepatoprotective effect of Moringa olifera leaves water extract (MO) towards the hepatotoxicity induced by RimR in rats. Seventy – four rats (130-170g) were divided into 8 groups(7 rats for normal and drug groups and 10 rats for Moringa extract for each group). Co-administration of Moringa oleifera with RimR reduced the elevated serum ala¬nine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), gamma glutamyl transferase (GGT), total protein, total bilirubin levels, malondialdehyde (MDA) and total antioxidant capacity (T.A.C). However, it elevated the reduced albumin. Hitopathological examination of MO extract groups showed the reduction in liver damage happened by RimR adminstration. From this study, we concluded that MO might be considered as hepatoprotective therapy with anti-tubercular drugs.