Abstract

Dr. Piyush Setu*, Dr. Rajeshwari Gore, Dr. Yashika Garg and Dr. Piyush Sengar

ABSTRACT

Background: Research in Anaesthesia aims to find an ideal anesthetic agent having quick induction and pleasant recovery with minimal adverse effects. Till date, no single drug meets the criteria of an ideal anesthetic agent. Also, very few studies are available comparing the induction and recovery characteristics of more than two intravenous agents simultaneously. So, the present study was conducted to compare the induction and recovery characteristics along with adverse effects of etomidate, propofol and thiopentone in surgical procedures of short duration under general Anaesthesia. Methods: It was a randomized, prospective, open-label parallel-group study conducted in 60 patients posted for short duration surgeries. The patients were randomized into three groups of 20 each receiving propofol, thiopentone or etomidate after they fulfilled the inclusion criteria and signed the informed consent.The induction, hemodynamic and recovery characteristics along with adverse effects were noted and analysed. Results: Etomidate showed rapid induction as compared to propofol and thiopentone with extremely significant p value. On comparing the three groups together, etomidate showed distinct cardiostability in terms of no significant change in heart rate, systolic and diastolic blood pressure whereas propofol showed faster recovery on Standardized Aldrete Score and Sedation Score. Few nonserious adverse effects were shown by etomidate and propofol but were absent in thiopentone group. Conclusion: The results of our study showed that etomidate is cardiostable and has rapid induction while recovery is faster and better with propofol.