World Journal of Pharmaceutical
and Medical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 6.842

ICV : 78.6

World Journal of Pharmaceutical and Medical Research (WJPMR) has indexed with various reputed international bodies like : Google Scholar , Index Copernicus , SOCOLAR, China , Indian Science Publications , Cosmos Impact Factor , Research Bible, Fuchu, Tokyo. JAPAN , Scientific Indexing Services (SIS) , UDLedge Science Citation Index , International Impact Factor Services , International Society for Research Activity (ISRA) Journal Impact Factor (JIF) , International Innovative Journal Impact Factor (IIJIF) , Scientific Journal Impact Factor (SJIF) , Global Impact Factor (In Process) , Digital Online Identifier-Database System (DOI-DS) , Science Library Index, Dubai, United Arab Emirates , Eurasian Scientific Journal Index (ESJI) , International Scientific Indexing, (ISI) UAE , IFSIJ Measure of Journal Quality , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

Abstract

COMPARATIVE STUDY ON TARGET VOLUME DELINEATION USING CT-MRI FUSION TECHNOLOGY WITH CT ALONE IN RADIOTHERAPY PLANNING OF HEAD AND NECK CANCERS

Bhaskar Viswanathan*, Kavitha and Swathi Krishna Reddy

ABSTRACT

Background: Uncertainty and inconsistency are observed in target volume delineation in head and neck tumors based on CT imaging. Recently, MRI is being increasingly used in oncology. Improved characterization of soft tissues and visualization of tumour extent using CT-MRI fusion can benefit the radiotherapy treatment planning. Objectives: To determine gross tumor volume (GTV) on CT simulation scans of the patients with head and neck squamous cell carcinoma planned for radiotherapy, to fuse CT simulation scans with MRI scans and determine gross tumour volume (GTV), to compare the gross tumour volume (GTV) in cubic centimeter contoured on CT simulation scans and fused CT-MRI scans. Methodology: Estimated sample size of 20 patients with head and neck carcinoma. After immobilization and CT simulation of patient, MRI scans and later fusion of CT-MRI images was done along with contouring of tumour target. Results: Significant differences were noted. CT-based target volumes were 20- 30% larger than CT-MRI fused volumes. The use of CT–based targets lead to overdosing of normal tissues. Volumes contoured from fused CT-MRI images was smaller than CT, indicating that MRI is a potent imaging tool for delineating tumours surrounded by soft tissue. These results illustrate, CT-MRI are complementary, i.e. tumour extension seen on CT are not always noted on MRI and vice versa. Conclusions: Combined information of CT, axial MRI/sagittal MRI should be used to delineate the GTV, especially when CT and MRI derived GTVs are inconclusive about tumour extensions. Efforts should be made to judge both imaging modalities simultaneously.

[Full Text Article]    [Download Certificate]

Powered By WJPMR | All Right Reserved

WJPMR