Abstract

Parin Patel*, Neil Modi, Krupa Patel, Shrikalp Deshpande, Janki Patel and Seema Shah

ABSTRACT

Drug utilization study (DUS) is stepping stone to conduct drug use evaluation so that error in drug use can be observed and resources can be put to use in proper fashion. Seizure disorder is a generalized term which includes epilepsy, febrile seizure, single seizure all associated with excessive or uncontrolled discharge of neurons. Around 4-10% children suffer at least one seizure in first 16 years of life leading to prescription of Anti-epileptic drugs (AED’s). The pharmacokinetics of AED’s differs between pediatric and adults, 90% of people are not receiving AED’s treatment due to various factors. Results: 132 pediatric patients prescribed with single or multiple doses of AED’s. Midazolam (41%) was the most commonly prescribed Benzodiazepine, Phenytoin (25%) most commonly prescribed AED. Conventional AED’s (95%) are more commonly prescribed in our study than Newer AED’s (5%). Conclusion: Our study concluded that boys were more prone to seizure episode than girls. Phenytoin was the most used AED and Midazolam was most commonly used BZD. Midazolam monotherapy was used as first line of drug for management of seizure episode. Thus concluding study shows conventional AED’s were still safe and effective in achieving seizure control.