Abstract

Dr. Shiza Tanveer, Dr. Nayyab Mujahid, Dr. Hajra Iqbal Alvi*

ABSTRACT

Objective: To assess the prevalence of non-alcoholic fatty liver disease in type II diabetes mellitus patients. Study Design: A Prospective Observational Study. Place and Duration: Department of Medicine Sheikh Zayed Hospital Rahim Yar, from June 2018 to January 2019. Methodology: Patients presenting with diabetes mellitus type II were divided into two equal groups on the basis of presence or absence of non-alcoholic fatty liver disease. Age, gender, BMI, Plasma aspartate aminotransferase, Plasma alanine aminotransferase, Plasma alkaline phosphatase, duration of type II diabetes mellitus, fasting plasma glucose, serum albumin, plasma cholesterol, plasma triglycerides, Plasma LDL-C, Plasma HDL-C and HbA1c were the variables calculated. Results: The mean age was 59.15±5.63 years, BMI 32.03±5.32 kg/m2, Plasma AST 19.68±2.22, Plasma ALT 19.87±1.71, Plasma ALP 62.32±12.84, duration of type 2 DM was 8.40±3.71 years and fasting plasma glucose of non NAFLD patients was 124.57±5.66 mg/dl. While, the mean age was 61.55±8.00 years, BMI 32.05±6.24 kg/m2, plasma AST 23.03±2.56, plasma ALT 27.28±1.94, plasma ALP 75.19±21.30, duration of type 2 DM 8.12±1.28 years and fasting plasma glucose of NAFLD patients was 137.45±5.07 mg/dl. The mean albumin (g/dl) was 4.20±0.64 g/dl, plasma cholesterol was 150.65±28.44, plasma triglyceride 114.04±5.99, plasma LDL-C 87.25±18.16 and plasma HDL-C of non NAFLD patients was 42.97±11.40. HbA1c in non NAFLD was 9.1%. While, the mean albumin was (g/dl) 3.80±0.69 g/dl, plasma cholesterol 158.62±42.02, plasma triglyceride 150.07±9.03, plasma LDL-C 87.0±27.89 and plasma HDL-C of NAFLD patients was 40.76±10.46. HbA1c of NAFLD patients was 6.8%. Conclusion: Non Alcoholic Fatty Liver Disease has a high prevalence in patients with type II diabetes mellitus having normal aminotransferases.