Abstract

Amal Elhassade*, Adham Saad, Monya Azzouz and Ehwida Bukhatwa

ABSTRACT

Background: Platelets with altered morphology or large size are more thrombogenic and are likely to be associated with increased risk of vascular disease. Platelet parameters especially high mean platelet volume (MPV) has been reported in diabetic patients as major contributing factor. Aim of the study: To determine if platelets were activated in diabetes by measuring the MPV in the diabetics compared to the non diabetics, to see if MPV was influenced in relation HbA1c and total platelet count. Materials and Methods: In the present study 100 were analyzed rand categorized into two groups based on the fasting blood glucose levels as Group I - healthy (non diabetics n= 40) Group II (patients with diabetic mellitus type II n=60), Results: MPV values were 8.97 ± 1.28 fl in diabetic individuals whereas 9.14 ± 1.01 in controls. The mean of total platelet counts in group II and group I were 233.79±85.7 x 109/l and 291.78 ± 97.81, respectively which were statistically significant different, platelets count was lower in uncontrolled diabetics and MPV larger than controlled diabetics. Conclusions: platelets count decrease in diabetics, MPV was larger in uncontrolled diabetics, the parameters still showed progressive decrease and increase with rising sugar levels significant in diabetic group.