SYNTHESIS AND BIOLOGICAL EVALUATION OF 1,4 DIHYDROPYRIDINES DERIVATIVES
Pradeep Kumar L.*, Dr. Sangamesh B. Puranik, Dr. Ashok Kumar B. S., Sridhar S. M.
Heterocyclic chemistry is of great importance to the medicinal chemists because of their drug utility. Large number of heterocyclic compounds being used as therapeutic agentsand these compounds are also essential for the human life.1, 4-Dihydropyridines are associated with broad spectrum of biological activities. A series of new Schiff bases containing the Hantzsch 1,4-dihydropyridine skeleton (1a-1g) has been synthesized byreaction of an appropriate aldehyde with 1, 4-dihydro-4-(substituted phenyl)-2,6-dimethylpyridine-3,5-dicarbohydrazide. The synthesized compounds were then characterized by TLC, melting point determination, IR, 1H-NMR.[Full Text Article]