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World Journal of Pharmaceutical
and Medical Research

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 5.922

ICV : 78.6

Abstract

THE PREVALENCE OF VITAMIN D DEFICIENCY AMONG ANTENATAL CASES & ITS CORRELATION WITH ADVERSE PREGNANCY OUTCOME

Reema Kumar Bhatt, Naresh Bansal*, S. Yadav and Dr. Pooja

ABSTRACT

Background: This study was carried out to Study the prevalence of vitamin D deficiency among antenatal cases & to determine the correlation between vitamin D levels and possibility of adverse pregnancy outcome. Methods: One thousand patients who fulfilled inclusion and exclusion criteria were selected and written consent was taken. The 25- hydroxy vitamin D3 level was estimated twice during the study period first at first trimester and again at the time of delivery. The pregnancy outcome was based on Vit D levels at the time of enrolment in study at first visit. The Vit D levels was grouped into three categories (<10 ng/ml, 10-30ng/ml and 30-100ng/ml). The study subjects were supplemented with Vit D3 (60,000 unit) orally per month till delivery if the Vit D3 level is <30ng/ml. The effect of Vit D3 level on the possibility of adverse pregnancy outcome was observed by Mode of Delivery, Birth weight, IUGR, IUD/Still birth, Anemia, Preeclampsia, Gestational diabetes mellitus (GDM). Results: The prevalence of Vit D deficiency among antenatal mothers was 91% and were supplemented with Vitamin D. In this study, vitamin D levels were significantly associated with parity, gestational age, mode of delivery and occurrence of pre-eclampsia and gestational diabetes mellitus. However, there was no significant association of Vit D levels with age, religion, IUGR, IUD/Still birth and anemia. Conclusion: The Vit D deficiency is widely prevalent and supplementation increases the vitamin D level significantly. In terms of neonatal outcomes, low vitamin D levels at enrollment was associated with low birth weight and IUGR but was not statistically significant. The preeclampsia and gestational diabetes mellitus was significantly more in vitamin D deficient mothers. The vitamin D supplementation during pregnancy might improve the adverse pregnancy and birth outcomes.

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