A REVIEW ON SOLID DISPERSION METHOD TO INCREASES THE SOLUBILITY OF SCANCY WATER SOLUBLE DRUG
Tikesh Agrawal* and Updesh Lade
ABSTRACT
Solid dispersion method is the methods, which significantly increases the solubility, dissolution rate and also increases the bioavailability of the poorly soluble drugs. The solid dispersion is based on the concept of kneding method in that the drug is dispersed in an inert water-soluble carrier at solid state. Water soluble carriers such as cyclodextrin, methyl cellulose, urea, lactose, citric acid, polyvinyl pyrrolidone and polyethylene glycols are used as carriers for solid dispersion. This reviews background of solid dispersion technology, limitations, classification and various preparation techniques with its advantages and disadvantages.
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