Abstract

Dr. Maria Razzaq*, Dr. Muhammad Ahsan Amin and Dr. Muhammad Mohsan Amin

ABSTRACT

Objective: To compare the efficacy of Amoxicillin-Clavulanate and Levofloxacin in the treatment of acute bacterial rhinosinusitis. Materials & Methods: A total of 360 patients with acute bacterial sinusitis of age ranges from 15-55 years of both gender were included. Patients with pneumonia, h/o allergy to allergy to Amoxicillin-Clavulanate or Levofloxacin and diabetes mellitus were excluded. Patients were randomly assigned into two groups based on Lottery method in Group A and Group B. Group A (The Amoxicillin-Clavulanate Group) received oral Amoxicillin-Clavulanate 1 g every 12 hours for 10 days. Group B (The Levofloxacin Group) received Oral Levofloxacin 250 mg every 12 hours for 10 days. Symptoms and signs were recorded at visit one before the start of antibiotics and at day 11 after completion of treatment. Results: The mean age of patients in group A was 35.73 ± 7.31 years and in group B was 35.91 ± 8.24 years. Out of these 360 patients, 143 (39.72%) were male and 217 (60.28%) were females with ratio of 1:1.5. Efficacy was seen as yes in 172 (95.56%) patients in group B (Levofloxacin group) group A (Amoxicillin-Clavulanate group) and 146 (81.11%) patients in with p-value of 0.000. Conclusion: This study concluded that levofloxacin has better efficacy and cost-effective than Amoxicillin-Clavulanate in the treatment of acute bacterial rhinosinusitis in terms of signs and symptoms relief.