Abstract

Dr. Priya Saji Koliyakodu*, Dr. Athira Thomson, Dr. Sneha Sebastian

ABSTRACT

Introduction: Leucorrhea (abnormal vaginal discharge) is one of the most common problem in women. Trichomonal vaginitis, candidial vaginitis, moniliasis, chlamydia, gonorrhea and bacterial vaginosis are the most common causes of pathological abnormal vaginal discharge. Oral combination kit therapy containing fluconazole (150mg), azithromycin (1000mg) and secnidazole (1000mg) are efficacious in treating such vaginal discharge. This kit is a combination used in syndromic management of vaginal discharge. Case report: A 38 year old female patient developed edema, foot heaviness, itchy red lesions scattered all over body. She also had vomiting and difficulty in movements with marked pain after the intake of combination kit containing fluconazole, azithromycin and secnidazole. On local examination following hospitalization there were itchy and large erythematous lesions with purpuric rash evident on bilateral upper and lower extremities. Treatment is mainly symptomatic based on corticosteroids and oral antihistamines. Conclusion: The drug induced lymphocyte stimulation test and leukocyte migration test may prove to be beneficial in identifying the offender drug.