Abstract

Mariam Riyadh Obied*, Fadhil Jawad Al-Tu’ma, Amir Kareem Sultan and Hameed Hussein Al-Jameel

ABSTRACT

Background: The one of Diabetes Mellitus (DM) complication is Diabetic foot ulcer (DFU), it is retard wound healing and the limbs may end with amputation. For the prevention of DFU, it has been necessary to take preventive measures that lead to reduce the amount of amputation to more than 50 %. The adipocytes secreted Monocyte chemoattractant protein-1 (MCP-1) is a member of the CC chemokine family and plays a vital role in the inflammatory process. has been linked with DFU and parameters of insulin resistance. Objective: To evaluated the correlation between serum MCP-1 concentration and other clinical characteristics in Iraqi DFU subjects. Materials and Methods: A cross-sectional study was done on 235 subjects, including 135 with DFU and 100 with Type 2 Diabetes Mellitus (T2DM) without DFU. Phenotypic data, comprising serum MCP-1 level, lipid profile, blood glucose, insulin, C-peptide and HOMA-IR were investigated. Results: This study included from 61% male and 38% female. While, the distribution of DFU group according to the age groups the higher incidence is in (55-64 years) age group. There was non-significant difference in age and gender between DFU and non-DFU group (P- value >0.05 for both). The serum MCP-1 concentration was significantly correlated with HOMA-IR and insulin among DFU group, while, HbA1c and TG was positively correlated with MCP-1 level in non-DFU group. Conclusion: 1. We found non-significant difference in age and gender between DFU and non-DFU group 2. A significant positive correlation was found between MCP-1 serum level, fasting insulin and HOMA-IR among T2DM with DFU group.