Abstract

N. B. Saidkarimova*, A. N. Yunuskhodjaev

ABSTRACT

Antibiotics are one of the most widely used drugs in medical practice. The main pharmacological properties of penicillin antibiotics are due to the selective bacteriostatic and bactericidal influence on gram-positive and gram-negative microorganisms. The effect of beta-lactam antibiotics on such a wide spectrum of organisms is directly dependent on their structure. Differentiation of such drugs from related substances and limiting counterfeiting requires development of highly sensitive methods of analysis. Therefore, improvement of pertinent analytical methods is one of the most urgent tasks that needs to be addressed. Objectives: To establish Raman spectroscopy as a method of analysis for the penicillin group antibiotics. Materials and methods: The research involved selecting ampicillin and amoxicillin for analysis as representatives of penicillin group antibiotics. Analyses were performed on Raman spectromet?r produced by USA company "Enhanced Spectroscopy", model "R-532". Results: Characteristic wavelengths of penicillins are located at 1500-1800 cm-1 and 2900-3100 cm-1 in the Raman spectrum. Conclusion: This article highlights the possibility of using Raman spectroscopy for determining the authenticity, as well as the quantitative analysis of penicillin antibiotics.