World Journal of Pharmaceutical
and Medical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 6.842

ICV : 78.6

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Abstract

DEVELOPMENT AND VALIDATION OF NEW UV SPECTROPHOTOMETRIC METHODS FOR THE ESTIMATION OF BENFOTIAMINE IN BULK AND SOLID DOSAGE FORM

Niraimathi V.* and Siva sankari K. A.

ABSTRACT

Benfotiamine is the precursor of thiamine which is a water soluble vitamin. Benfotiamine is fat soluble, a characteristic that allows it to enter cells more readily than thiamine and thus helps to prevent diabetes-related dysfunction within the cells. This enhanced bioavailability makes benfotiamine particularly effective in treating hyperglycemia related damage to tissues and organs. Two simple, precise, accurate UVspectrophotometric methods namely dual wavelength spectrophotometric method and difference UV spectrophotometric method have been carried out using 0.1 N HCl as solvent. The drug obeyed Beer’s law in the range between 4-20?g/mL. The overall percentage recovery was found to be 99-101% which indicates the accuracy of the proposed method. The methods have been validated as per ICH guidelines and could be applied in future analysis of Benfotiamine formulations.

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