Abstract

André Luiz Freitas De Lima Filho, Carine AM Tasso, Lisiane Cervieri Mezzomo, Silvia Maria Spalding, Luciane Noal Calil, Renata Pereira Limberger and Adelina Mezzari*

ABSTRACT

Purpose: ATM gene polymorphisms are thought to influence the risk of cancer and radiation-induced tissue toxicity risk in cancer patients treated with radiotherapy. However, the results of previous studies are not clearly definied. This review aims to examine the association between ATM gene polymorfisms and tissue toxicity after radiotherapy. Methods: A compreensive literature search using keywords such as "ATM gene" and/or ‘polymorfism’ and/or ‘radiotherapy' was done to identify all the relevant studies that investigated the association between the ATM polymorphisms and cancer induced toxicity after radiotherapy in AT syndrome patients. The search was done in the PubMed database, and was conducted until December 2018. After extracting relevant details, each selected literature was evaluated for quality. The allele/genotype frequencies were extracted from each study. Results: That review were conducted using 26 elegible studies. Our findings suggest that polimorphisms of ATM gene were (or not) associated with the predisposition of tissue toxicity, as erytema, fibrosys. Conclusions: The results indicate that the ATM gene polymorphism are risk factors for tissue toxicity after radiotherapy. Large-scale and well-designed international studies are needed to furter analyze this field.