Abstract

Yashika Uniyal*, Manoj Kumar Sarangi and Kriti Dabral

ABSTRACT

Colon targeted delivery is one of the most challenging task to the researcher in the field of developing dosage form. Colonic diseases are common and hazardous causing severe pain to the patients and needed direct targeting of drug to the desired site. So Multiparticulate dosage form are one of the best approach for treating colonic disorder involving carrier which release the drug at the effected site. My present work includes formulation of multiparticulate dosage form using natural polymer Fenugreek seed mucilage (FSM) which binds the drug in combination with other drug and a carrier that delivers the drug at infected site in colon 5-. Fluoro uracil was selected which belongs to the category of Antineoplastic (anticancer) used for the treatment of colorectal cancer. Multiparticulate dosage. i.e. microbeads were prepared using chemical cross linking in combination of polymer reinforcement technique. with FSM and sodium alginate as a bead forming agent and 5-fluorouracil as a drug.12 batches were prepared of microbeads using variable concentration of polymers and drug and out of them, best formulations were evaluated for evaluation parameter i.e. Percentage yield, entrapment efficiency, In vitro drug release and scanning electron microscopy. Scanning electron microscopy determines the shape and surface morphology structure of beads. The studies concluded that fenugreek act as a good binder to take the drug to the colon in combination with other polymers.