FORMULATION DEVELOPMENT, EVALUATION AND COMPARATIVE STUDY OF EFFECTS OF SUPERDISINTEGRANTS IN FAST DISINTEGRATING TABLETS OF RUBIA CARDIFOLIA
Brinda Sreelesh, Varsha Vaze, Vishakha Datta Lad, Mangesh Dattaray Kadam and Gitika Arora Dhingra*
ABSTRACT
In current study, fast disintegrating tablet of Rubia cardifolia has been prepared by using super-disintegrants. Rubia cardifolia is an anti-emetic drug that is also used for treatment of skin diseases, spleen disorders, anti tumor effects in different doses. The purpose is to get the quicker onset of action and better patient compliance. Super-disintegrants are major participants in fast disintegrating tablets. Cross Povidone, Sodium starch glycollate and Crosscarmellose sodium are used in this study and their comparative disintegrating efficacy is studied. Pre-compression and post-compression characteristics are evaluated. It has been concluded that cross povidone gives the best results as super-disintegrant while preparing fast disintegrating tablets of Rubia cardifolia.
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