World Journal of Pharmaceutical
and Medical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 6.842

ICV : 78.6

World Journal of Pharmaceutical and Medical Research (WJPMR) has indexed with various reputed international bodies like : Google Scholar , Index Copernicus , SOCOLAR, China , Indian Science Publications , Cosmos Impact Factor , Research Bible, Fuchu, Tokyo. JAPAN , Scientific Indexing Services (SIS) , UDLedge Science Citation Index , International Impact Factor Services , International Society for Research Activity (ISRA) Journal Impact Factor (JIF) , International Innovative Journal Impact Factor (IIJIF) , Scientific Journal Impact Factor (SJIF) , Global Impact Factor (In Process) , Digital Online Identifier-Database System (DOI-DS) , Science Library Index, Dubai, United Arab Emirates , Eurasian Scientific Journal Index (ESJI) , International Scientific Indexing, (ISI) UAE , IFSIJ Measure of Journal Quality , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

Abstract

INTERPRETATION DRUG INTERACTIONS IN HOSPITALIZED CARDIAC PATIENTS

*Dr. Ahmed Muaaz, Dr. Muhammad Astaghees Tayyab and Dr. Iqra Fatima

ABSTRACT

Objective: The present study is aimed to identify potential drug-drug interactions in cardiac patients and document any observed interaction. It was also planned to evaluate the demographics of patients and correlate it with drug drug interactions in Lahore General Hospital, Lahore. Methodology: It is a prospective observational study conducted in inpatient setting. The data collected in pre design data collection form for 220 patients, who are assessed for the period of six months. The cardiac patients who were taking at least two cardiac drugs and had a hospital stay of 48 hours were considered for this study. The collected data included demographics; cardiac drugs usage pattern and safety analysis data. The data was compiled in excel and analysed using Micromedex. Result: A total of 220 patients were included in the study out of which 140 patients prescriptions contains pDDI. A total of 234 pDDIs were identified during the study period with median of 1.67 potential drug-drug interactions. Extensive (97.85%) poly pharmacy was observed in study population. The median hospital stay was 7 days. The incidence rate was found to be 63.64%. Majority of interactions were of moderate severity, delayed onset, and pharmacodynamics in nature. Total 28 actual interactions were observed in the observed cases. Out 234 drug interactions, aspirin/clopidogrel (16) and clopidogrel/atorvastatin (16) were most common drug interaction pairs observed among prescribed medications. Of the 234 interventions proposed, the most frequent suggestion was on monitoring for adverse effect (44.01%) followed by dose adjustment (15.81%). 25.64% of interventions were accepted and therapy was changed. Most of the adverse drug interaction observed resulted in bleeding. The causality assessment as per Naranjo and WHO scale were probable in most of observed drug interactions. Conclusion: The present study identified pDDIs and also documented interactions in cardiovascular patients. It was found that the incidence rate of pDDI was high and associated with old age, poly pharmacy and increased lengths of hospital stay. This study highlights the need for screening prescriptions of cardiovascular patients for pDDIs and proactive monitoring of patients who have identified risk factors; this helps in detection and prevention of possible adverse drug interactions.

[Full Text Article]    [Download Certificate]

Powered By WJPMR | All Right Reserved

WJPMR