Abstract

*Dr. Bharathi A., Bojadla Vanaja and Chandra Sekhar Naik D.

ABSTRACT

Pulsatile Drug Delivery systems (PDDS) is a novel method, it is basically time-controlled drug delivery systems in which the system controls the lag time and drug is released in an immediate or extended fashion. The present investigation was conducted for formulation and evaluation of pulsatile release tablets of candesartancilexetil for the treatment of cardiovascular diseases. The compression coated tablets consisted of a core tablet containing drug with syntheticsuperdisintegrant, which was further coated by erodible outer layer consisted of HPMC K4 and HPMC K100. After carrying outpreformulation studies the formulated tablets were evaluated for post post-compression parameters like weight variation, thickness, hardness, friability, drug content and in-vitro study of drug release. The best formulation was selected on the basis of post-compression parameters and was subjected to accelerated stability studies for 3 month. Amongst 6 formulations prepared, F6 produced convincing results with a maximum cumulative drug release of 99.1% in 8 hours. Also the formulation didn’t show any significant changes during 3 month period of stress testing. By virtue of its release pattern and delivering the drug at the right time, right place and in right amounts, the developed delivery system holds good promises of benefiting the patients suffering from hypertension.