EFFECTS OF ETHANOLIC SEED EXTRACT OF TETRACARPIDIUM CONOPHORUM ON BODY WEIGHT, FOOD-INTAKE, WATER-INTAKE AND BLOOD GLUCOSE LEVEL OF FEMALE WISTAR RATS
Nancy N. Njoku-Oji*, Scholastica O. Ahiwe, Stephen O. Maduka, Peter N. Ogueche, Izuchukwu A. Okafor, Ijeoma C. Enemuo, Johnson U. Agbai and Njoku O. Ifegwu
ABSTRACT
Objective: This study was carried out to investigate the effects of ethanolic seed extract of Tetracarpidum conophorum on blood glucose level, food-intake, water-intake and body weight of normal female wistar rats. Methodology: Thirty-two female wistar rats weighing between 140- 200g were purchased from the Animal house of Human Physiology Department Nnamdi Azikiwe University Nnewi. They were acclimatized for two weeks after which they were divided into 4 groups of 8 rats each and housed in cages. The groups were designated as groups A, B, C and D. Group I served as control group that received only distilled water while the other groups B-D served as test groups that were administered ethanolic seed extract of T. conophorum orally throughout a period of 14 days. The extract was administered using oral cannula at doses of 200mg/kg, 400mg/kg and 600mg/kg to groups B, C and D respectively. Results: There was a significant (P0.05) decrease in food intake in all test groups when compared with the control. There was insignificant (P>0.05) increase in water intake in all test groups when compared with the control. There was a significant (P
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