FORMULATION AND EVALUATION OF SUCRALFATE AND METOPROLOL SUCCINATE BI-LAYER FLOATING TABLET AS GASTRO RETENTIVE DRUG DELIVERY SYSTEM
Sreedhar Ranjan Das*, Dr. Bibhuti Bhusan Panigrahi and Dr. Manoj Kumar Pani
ABSTRACT
The present research deals with formulation and evaluation of Bi-Layer Floating Tablet of Ulcer protective Sucralfate as Immediate Release Layer and Antihypertensive Metoprolol Succinate as Floating Sustained Release layer. This formulation generate maximum bioavailability and prolonged gastro retention and satisfy GRDDS in patients having Stomach Ulcer with Hypertension in pregnancy and lactation. Both the drugs are administrated in empty stomach and shows minor drug interaction. The present research based upon Spectral analysis, Identification test and Preformulation study of pure drug. Then Formulation, In vitro evaluation, Accelerated stability study of 15 formulations of Sucralfate and 10 formulations of Metoprolol Succinate are done and the best formulations are selected as SF13, MS2. Then Bi Layered floating tablet is compressed and In vitro and In vivo evaluation is done and accelerated stability is done and it is confirmed that the formulation produce better GRDDS.
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