Abstract

Mohammed A. Dakhil*, Assisstant Prof. Dr. Shatha M.J. Al-Khateeb and Assisstant Prof. Dr. Arshad F. Ridha

ABSTRACT

Background: Timely diagnosis of acute coronary syndrome in the emergency department remains challenging. Biomarkers that are not dependent on myocardial necrosis, such as high sensitivity troponin can provide more information on whether there is myocardial ischemia, plaque rupture to help an early diagnosis. Objective: This study carried out to evaluate serum high sensitivity troponin in patients with acute coronary syndrome and its correlation with other biomarkers and risk factors. Patients & Methods: A total of (58) male patients with diagnosis of acute coronary syndrome were included in this study with age range (23-75year) and divided into: ST-segment elevation myocardial infarction group, non ST-segment elevation myocardial infarction group and unstable angina group as well as (30) apparently healthy persons with age range (27-70year). Results: Serum high sensitivity troponin was significantly increased in acute coronary syndromes in comparison with control group, the levels of cholesterol, triglycerides and LDL cholesterol in patients increased statistically significantly compared to the healthy, significant negative correlation was found between Ejection Fraction and serum high sensitivity troponin in acute coronary syndrome patients. Positively significant correlation was found between high sensitivity troponin and other traditional biomarkers. Conclusion: This study revealed that serum high sensitivity troponin could be used as an indicator to assess the severity of myocardial injury.