Abstract

Anwane Harshal*, Singhai Anuj, Jain Sarang and Johar Arvind

ABSTRACT

The intent of the study is to broaden derivatives of 1,3,4- oxadiazole. Oxadiazole is a five-member heterocyclic ring which is a resourceful lead compound for crafty potent bioactive agents. Heterocyclic compounds have been an attention-grabbing area for the study of the synthesis and biological activity of novel oxadiazole derivatives for a long time. One of these compounds 1,3,4-Oxadiazole is a resourceful heterocyclic nucleus is a novel molecule which attracts the medicinal chemist to search a new therapeutic molecule. Oxadiazole derivatives were synthesized as per the literature methods, the completion of the reaction will be ascertained by thin layer chromatography. In the present work of synthesis of the oxadiazole derivatives of ibuprofen was to convert its ethyl ester (I) by esterification. This ester was reacted with hydrazine hydrate to give Carbohydrazide of Ibuprofen (II). This Carbohydrazide was treated with CS2 and KOH in ethanol and it gives 5-{1-[4-(2-methyl propyl) phenyl]ethyl}-1,3,4-oxadiazole-2(3H)-thione (III). 5-{1-[4-(2-methyl propyl)phenyl]ethyl}-1,3,4-oxadiazole-2(3H)-throne with various 1?/2? amines and formaldehyde in ethanol 1,3,4-oxadiazole derivatives. The purity of the synthesized compounds was confirmed by melting point and TLC on silica gel G. The structure of synthesized compounds was characterized by spectral studies.