ENDOGENOUS PATHOLOGICAL FACTORS AS THE REASON OF SYSTEM INFLAMMATORY REACTION DURING RHEUMATOID ARTHRITIS
Aida Eshmurzaeva, Ma’rif Karimov, Iskandar Mavlyanov, Abdug’ofir Khadzhimetov, Mariya Sibirkina, Bekhzod Abdullaev*
ABSTRACT
Background: Rheumatoid arthritis (RA) is an autoimmune, systemic disease that affects the joints. In RA, the body?s immune system destroy body?s tissue for a foreign invader. This leads immune system to attack the protective cushion of tissue and fluid between the joints. The result is swelling, stiffness, and pain in the joint. The body?s misfiring immune system also may go after the body?s soft tissues, like cartilage, and organs such as the heart, eyes, and veins. According to the literature, the number of publications on the study of endogenous pathological factors as the reason of systematic inflammatory reaction in patients with RA is limited. Methods: Retrospective analysis representing in this article was performed through 68 patients with RA who was received inpatient treatment in the Department of Rheumatology 3-clinic Tashkent Medical Academy (TMA) in period from 2013 to 2015. The activity of rheumatoid arthritis was estimated on DAS-28 indicators, the erythrocyte sedimentation rate (ESR) levels and quantity of leukocytes. The research included 16 patients suffering from RA without anemia (Hb>120g/l) – the first group of patients, 20 patients (second group) of RA with anemia (Hb
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