World Journal of Pharmaceutical
and Medical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 6.842

ICV : 78.6

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Abstract

RADIATION-INDUCED ESOPHAGEAL CARCINOMA 11 YEARS AFTER MEDIASTINAL IRRADIATION: CASE REPORT AND LITERATURE REVIEW

Y. Moukasse*, F.Z. Lahlali, M. Toubda, A. Allam, J. Aarab, H. Sfaoua, Majjaoui, H. El Kacemi, T. Kebdani, S. El B. El Khannoussi and N. Benjaafar

ABSTRACT

Background: Radiation-induced esophageal cancer is rare occurring several years after mediastinal irradiation. The purpose of this study is to report a case of this pathology and to review the literature, analyzing its diagnostic, therapeutic and prognostic characteristics. Case Presentation: A 41-year-old woman, with no evidence for risk factors (abuse of nicotine or alcohol), treated for a left breast cancer in 2005 with surgery, adjuvant chemotherapy and radiation therapy, present after 11 yeast of local control, carcinoma of the cervical esophagus T4bN0M0 According to the TNM classification of Carcinoma of the Esophagus and Esophagogastric Junction (8th edition, 2017) (AJCC American Joint Committes on Cancer). She was treated with radiation therapy (50,4Gy, 1,8Gy per fraction (28 fractions, with Linac RC3D)) and concomitant chemotherapy (Cisplatin 70mg per week). Our patient died 7 months after radiation therapy (local and metastatic progression). Conclusion: Radio-Induced esophageal cancer is a rare entity, he should be suspected in a patient with dysphagia and history of mediastinal irradiation. The treatment of this cancer remains difficult with a poor prognosis.

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