Abstract

Anilgoud Kandhula, Anjali Devi Nippani and Dr. Krishnaveni Janapareddi*

ABSTRACT

Schizophrenia is a highly disabling disease responsible for the loss of social contacts of the affected person. Quetipine fumarate, a drug of choice, is available only as tablets and extended release tablets and suffers from the drawback of poor oral bioavailability (9%) and drug loss due to first pass metabolism. The attempt is made to formulate intranasal mucoadhesive microemulsion with the view to provide faster onset of action and improved bioavailability. The exipients used were Oleic acid (oil), Tween 80 (surfactant), PEG400 (co surfactant) and chitosan (Mucoadhesive agent).The optimized formulation was evaluated for transparency, mucoadhesive strength, globule size (61.9 nm), zeta potential (-22.7 mV), PDI (0.13), % drug content, SEM analysis. Hence it can be concluded that the formulation with enhanced solubility can have potential of improving bioavailability of Quetiapine fumarate can be a better alternative than the available formulation.