SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF HYDRAZONES DERIVED FROM IBUPROFEN
G. Jeevan Raghavendra, K. Bharatkumar and V. Siddaiah*
ABSTRACT
Thirteen new hydrazones 5a-m were prepared from commercially available Ibuprofen. The structures of the synthesized hydrazones were determined by the spectroscopic techniques like 1H NMR, 13C NMR, mass and IR spectral data. These compounds were screened against two Gram negative and two Gram positive bacteria viz., E. coli, P. aeruginosa, S. aureus and S. pyogenes respectively. Compounds 5h, 5i, 5j, 5k, 5l and 5m exhibited good antibacterial activity compared to the standard drug Norfloxacin.
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