CORRELATION OF DNA DAMAGE IN SEIZURE AND ORGAN DYSFUNCTION OF PERINATAL ASPHYXIA
A. Manoj*, B. Vishnu Bhat, C. Venkatesh, Z.Bobby
ABSTRACT
The present study was conducted to evaluate the level of DNA Damage in Seizure and Organ Dysfunction in Perinatal Asphyxia and its correlation of DNA damage and Organ dysfunction. Eighty term asphyxiated babies were included in this study in which fifty nine babies had seizure. Blood samples were collected within 24 hours of birth. Comet assay was used to detect the level of DNA damage. Oxidative stress was assessed by estimation of Serum MDA level. Seizure was found in three, four and five system with % DNA in Tail of Comet as 44.39868±6.018107, 46.02007±3.899824 and 73.19868±4.359216 respectively. MDA level in seizure was positively correlated with Mutiorgan Dysfunction (r value 0.7210). Positive correlation between % DNA in tail of comet and MOD (r value 0.8408).Therefore Comet Assay and Estimation of Serum MDA level are best Parameters to determine the level of DNA damage and oxidative stress respectively in Perinatal Asphyxia.
[Full Text Article] [Download Certificate]