Abstract

Luciane Noal Calil, André Luiz Freitas de Lima Filho, Simone Krause Ferrão, Joyce Bonazzoni, Carine A. M. Tasso, Vanessa Zafaneli Bergamo, Renata Pereira Limberger and Dr. Adelina Mezzari*

ABSTRACT

Breast cancer consists of a public health problem in Brazil, representing the first cause of cancer death in Brazilian women of all ages. The state of Rio Grande do Sul has one of the highest incidence and mortality rates in the country, and your capital, Porto Alegre, has the record Brazilian’s city in new cases. This article discusses the importance of the research of the ATM gene (Ataxia Telangiectasia Mutated) in routine evaluations in patients with hereditary predisposition to breast cancer, diagnosed or not with the disease. The search was performed through the databases PubMed, SciELO and Science Direct, in which scientific articles were selected to explore the proposed theme, between the years of 2000 and 2017. The results indicate that the identification of individuals with dysfunctional ATM is relevant to determine etiological factors and to direct strategies for prevention, early diagnosis, besides supporting the medical team in the definition of the therapeutic protocol, with special attention to the radiosensitivity presented by these patients, whose ATM research may guide a targeted approach, with improvement in the quality of life and the prognosis of the patients.