Abstract

*P. Deepthi, *J. Poorna Sindhu, Dr. G. Susmitha, Dr. V. Tejaswi, Dr. G. Ramesh, Dr. P. Srinivasa Babu

ABSTRACT

Hepatotoxicity, also known as liver damage causes the liver to under function or function irregularly. Many chemical substances or drugs are responsible for hepatotoxicity. Chemotherapy is a type of treatment that includes the medication or the combination of medications that destroys the cancer cells. These chemotherapeutic agents may cause liver damage by adding the stress to liver’s filtering function and this is referred to as chemotherapy induced hepatotoxicity. Patients who are receiving chemotherapy requires close monitoring of liver function prior to treatment to know which drug is inappropriate or which drug doses have to be modified. Chemotherapeutic agents, alone or in combination, may cause hypersensitivity reactions or direct liver toxicity, and altered hepatic function and may change drug metabolism. Most cases of chemotherapy-induced hepatotoxicity are characteristic and do not have a specific clinical or histological signature that is distinct from other agents which cause hepatotoxicity. The article creates an awareness about the toxicity of every chemotherapeutic agent which is very essential before starting of new treatment to the cancer.