Abstract

Yamuna A. B, Rashmi Banik* and Manjula Talluri

ABSTRACT

Extended release matrix tablet formulation of carvedilol were developed and evaluated to observe the effect of different drug release retarding polymer i.e., (HPMC K4, Eudragit S100) on invitro drug release .Ten formulation (F1-F10) were prepared by direct compression technique. FTIR studies showed stable character of Carvedilol with polymer. The pre-formulation parameters such as bulk density, tapped density, angle of repose, compressibility index and hausner’s ratio were analysed for prepared granules before compression. The thickness, hardness, friability, weight variation and drug content uniformity was evaluated for tablets. The effect of this variable on the drug release profile of carvedilol was also studied. In-vitro drug release is performed in USP apparatus-II(Paddle) at pH 7.4 phosphate buffer and at pH 1.2 in HCl medium at 37 °C for 16 hr. F3 has shown improved % cumulative drug release compared to others. Also F3 has satisfied the IP specifications of 81% within 16 hr. The stability study of the tablets F3 was carried out according to ICH guidelines at 40±?C/75±5% RH for three months by storing the samples in stability chamber, No significant difference in % CDR was observed. The best fit of release kinetic was achieved with Higuchi model followed by zero order.