Abstract

Aparna P.*, Rakesh Kumar Jat and Subash Chandran. M. P.

ABSTRACT

Systematic evaluation of plants used in the traditional medicines may provide more promising information regarding their therapeutic value and could be beneficial in addressing the increasing demand for newer agents to fight infections and diseases. With this view, the plant Cissus quadrangularis was selected for our research. As the continuation of our previous effort, the present study was focused on the in vivo evaluation of anti-arthritic and anti-diabetic activity of methanol extract of C. quadrangularis. Initially, acute toxicity of the extracts was evaluated and the effective dose (ED50) was fixed. Anti-arthritic activity of the extract was evaluated by Complete Freund’s adjuvant (CFA) induced arthritic animal models. Anti-diabetic activity of the extract was evaluated by streptozotocin-induced diabetes mellitus animal models. Two doses of test extract, low dose and high dose (200 and 400mg.kg-1) were subjected to the evaluation. In these evaluations, methanol extract in the dose of 400mg.kg-1 showed a significant result. Further studies of this extract in future may yield significant results that will be useful for the development of new chemotherapeutic agents.