Abstract

Mahmoud Mahyoob Alburyhi*, Yahya Abduh Salim Mohamed, Abdalwali Ahmed Saif, Maged Alwan Noman, Jalal H. Abdullah and Tawfeek AA. Yahya

ABSTRACT

The objective of the present study was to prepare Furosemide and Amlodipine as Orodispersible tablets drug delivery systems. Orodispersible tablets dissolve rapidly and show higher bioavailability than conventional tablets. Furosemide and Amlodipine was selected as a model for preparation of Orodispersible Tablets by direct compression technique. Amlodipine is a long-acting calcium channel blocker (dihydropyridine) used as an anti-hypertensive and in the treatment of angina. Amlodipine is one of the calcium channel blockers that works primarily on arterial muscle and it acts by relaxing smooth muscle in the arterial wall, decreasing peripheral resistance and hence reducing blood pressure; in angina it increases blood flow to the heart muscle. Furosemide is a loop diuretic commonly used in adults, infants and children for the treatment of edematous states associated with congestive heart failure, cirrhosis of the liver and renal disease. Oral Furosemide may be used in adults for the treatment of hypertension alone or in combination with other antihypertensive agents; however, they are slow to produce the desirable effect. Therefore, to decrease the patient time in suffering of these symptoms, Orodispersible drug-delivery system significantly increased patient acceptance by virtue of rapid disintegration, self-administration without water and finally improved patient compliance. Tablets were prepared by direct compression method using crospovidone and sodium starch glycolate as superdisintegrants. The tablets were evaluated for weight variation, thickness, diameter, hardness, friability, time, in-vitro disintegration time, assay HPLC method and in-vitro dissolution study. Hardness and friability data indicated good mechanical strength of tablets. The results of in-vitro disintegration time of F4 and F2 was found to be 9 and 2 seconds and the drug release 90.72% and 76.51% at 5 minutes respectively indicated that the tablets dispersed rapidly in the mouth. It was concluded that F4 and F2 are the best formulations of Furosemide and Amlodipine Orodispersible Tablets ODTs drug delivery systems in order to increase onset of action and bioavailability of drug.