World Journal of Pharmaceutical
and Medical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 6.842

ICV : 78.6

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Abstract

ZINC DEFICIENCY AND ORAL ZINC SULPHATE TREATMENT IN PATIENTS WITH PERSISTENT VIRAL WARTS

Fatma H. Shabaka, Laila A. Rashed, Abeer M. Kamel*, Inass M. Mohammed and Nohir M. Assem

ABSTRACT

Background: Warts are common viral infections of the skin and mucous membranes, caused by Human papilomaviruses (HPVs). Zinc has immunomodulatory effects that could counteract viral infections by having an effect on the synthesis of cytokines. Objective: The aim of this work was to evaluate the efficacy and safety of oral zinc sulphate in treatment of persistent viral warts. Subjects and Methods: This case control study included 30 patients with multiple persistent warts and 30 age and sex matched healthy persons as controls. Patients were divided according to the type of warts into three groups: 10 patients had common warts, 10 patients had plane warts and 10 had planter warts. The serum zinc level was measured before treatment, patients received oral zinc sulfate for 2 months and serum zinc level was measured after treatment. During the treatment period the patients were examined every 2 weeks for evidence of partial or complete regression of their lesions. They were photographed before treatment, one month after and 2 month immediately after treatment. Results: There was statistically significant decrease in serum zinc level before treatment in patients than control (P < 0.001). The serum zinc level in common warts has significant decrease than plane and planter(P< 0.005) with no difference after treatment. All these types have statistically significant increase in serum zinc level after treatment, serum zinc level before treatment ranged from 21.7 to 68.2 ?g/dl with mean 41.3 + 12.8 and serum zinc level after treatment with oral zinc sulfate ranged from 78.9 to 172.8 ?g/dl with mean 121.4 + 26.9?g/dl. All our patients were responders to the zinc sulphate treatment. Conclusion: oral zinc sulphate seems to be a simple, effective and safe treatment of warts.

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