Abstract

*Godge Ganesh Raosaheb, Garje Mahesh Arjun, Dode Aniket Balaprasad, Dhaygude Anil Machindra, Wagh Divya Vinayak and Fartade Sachin Jalindar

ABSTRACT

A simple, accurate, sensitive, precise and rapid UV- Spectrophotometric simultaneous equation method have been developed for the simultaneous analysis and estimation of Fenofibrate and atorvastatin in bulk and combined tablet dosage form formulation. To determine the absorption maximum, each drug Fenofibrate and atorvastatin were scanned in wavelength range of 200-400 nm in spectra measurement mode using the double beam UV- Spectrophotometer (Jasco). 287 nm (?max for fenofibrate) and 249 nm (?max for atorvastatin) respectively were selected as a sampling wavelengths in methanol as solvent. Beer’s limit were obeyed in the range of 5-30 µg/ml for both Fenofibrate and atorvastatin. The correlation Coefficients for both drugs found to be satisfactory. Validation parameter such as its accuracy, linearity, precision, limit of detection (LOD), limit of quantitation (LOQ) were studied for proposed method according to the ICH guidelines. Results of all parameters were found to be satisfactory. The proposed method can be used effectively for routine analysis and estimation of fenofibrate and atorvastatin in combined synthetic mixture and bulk dosage form.