World Journal of Pharmaceutical and Medical Research (WJPMR) has indexed with various reputed international bodies like : Google Scholar , Index Copernicus , SOCOLAR, China , Indian Science Publications , Cosmos Impact Factor , Research Bible, Fuchu, Tokyo. JAPAN , Scientific Indexing Services (SIS) , UDLedge Science Citation Index , International Impact Factor Services , International Society for Research Activity (ISRA) Journal Impact Factor (JIF) , International Innovative Journal Impact Factor (IIJIF) , Scientific Journal Impact Factor (SJIF) , Global Impact Factor (In Process) , Digital Online Identifier-Database System (DOI-DS) , Science Library Index, Dubai, United Arab Emirates , Eurasian Scientific Journal Index (ESJI) , International Scientific Indexing, (ISI) UAE , IFSIJ Measure of Journal Quality , Web of Science Group (Under Process) , Directory of Research Journals Indexing , 

World Journal of Pharmaceutical
and Medical Research

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 5.922

ICV : 78.6

Abstract

VALIDATED SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF FENOFIBRATE AND ATORVASTATIN IN SYNTHETIC MIXTURE AND IN BULK TABLET DOSAGE FORM

*Godge Ganesh Raosaheb, Garje Mahesh Arjun, Dode Aniket Balaprasad, Dhaygude Anil Machindra, Wagh Divya Vinayak and Fartade Sachin Jalindar

ABSTRACT

A simple, accurate, sensitive, precise and rapid UV- Spectrophotometric simultaneous equation method have been developed for the simultaneous analysis and estimation of Fenofibrate and atorvastatin in bulk and combined tablet dosage form formulation. To determine the absorption maximum, each drug Fenofibrate and atorvastatin were scanned in wavelength range of 200-400 nm in spectra measurement mode using the double beam UV- Spectrophotometer (Jasco). 287 nm (?max for fenofibrate) and 249 nm (?max for atorvastatin) respectively were selected as a sampling wavelengths in methanol as solvent. Beer’s limit were obeyed in the range of 5-30 µg/ml for both Fenofibrate and atorvastatin. The correlation Coefficients for both drugs found to be satisfactory. Validation parameter such as its accuracy, linearity, precision, limit of detection (LOD), limit of quantitation (LOQ) were studied for proposed method according to the ICH guidelines. Results of all parameters were found to be satisfactory. The proposed method can be used effectively for routine analysis and estimation of fenofibrate and atorvastatin in combined synthetic mixture and bulk dosage form.

[Full Text Article]

Powered By WJPMR | All Right Reserved

WJPMR